Mathematically mapping the network of cells in the tumor microenvironment

M. van Santvoort, Ó. Lapuente-Santana, M. Zopoglou, C. Zackl, F. Finotello, P. van der Hoorn^#, F. Eduati^#. Cell Reports Methods. 2025. (^# co-last authors)

Integrating histopathology and transcriptomics for spatial tumor microenvironment profiling in a melanoma case study

Ó. Lapuente-Santana^$, J. Kant^$, F. Eduati. npj Precision Oncology, 2024. (^$ co-first authors)

Multimodal analysis unveils tumor microenvironment heterogeneity linked to immune activity and evasion

Ó. Lapuente-Santana^$, G. Sturm^$, J. Kant, M. Ausserhofer, C. Zack, M. Zopoglou, N. McGranahan, D. Rieder, Z. Trajanoski, N. F. d C. C. de Miranda, F. Eduati^#, F. Finotello^#. iScience, 2024. (^$ co-first authors, ^# co-last authors)

Agent-based modeling of the prostate tumor microenvironment uncovers spatial tumor growth constraints and immunomodulatory properties

M. van Genderen^$, J. Kneppers^$, A. Zaalberg^$, E. Bekers, A. M. Bergman^#, W. Zwart^#, F. Eduati^#. npj Systems Biology and Applications, 2024. (^$ co-first authors, ^# co-last authors)

Bilayer microfluidic device for combinatorial plug production

M. Yelleswarapu, S. Spinthaki, T. F. A. de Greef, F. Eduati. JoVE. 2023.

Exploring the onset and progression of prostate cancer through a multicellular agent-based model

M. Passier, M. van Genderen, A. Zaalberg, J. Kneppers, E. Bekers, A. M. Bergman^#, W. Zwart^#, F. Eduati^#. Cancer Research Communications. CRC-23-0097, 2023. (^# co-last authors)

Liquid biopsy-based decision support algorithms for diagnosis and subtyping of lung cancer

E. Visser^$, S. A.A.M. Genet^$, R. P.P.A. de Kock, B. E.E.M. van den Borne, M. Youssef-El Soud, H. N.A. Belderbos, G. Stege, M. E.A. de Saegher, S. C. van 't Westeinde, L. Brunsveld, M. A. C. Broeren, D. van de Kerkhof, B. A.L.M. Deiman, F. Eduati^#, V. Scharnhorst^#. Lung Cancer. 178, 28-36, 2023. (^$ co-first authors, ^# co-last authors)

Technological and computational advances driving high-throughput oncology

L. Kolmar^$, A. Autour^$, X. Ma, B. Vergier, F. Eduati^#, C. A. Merten^#. Trends in Cell Biology, 32(11), 847-961, 2022. (^$ co-first authors, ^# co-last authors)

Interpretable systems biomarkers predict response to immune-checkpoint inhibitors

Ó. Lapuente-Santana, M. van Genderen, P. A. J. Hilbers, F. Finotello, F. Eduati. Patterns, 2(8), 100293. 2021.

Toward Systems Biomarkers of Response to Immune Checkpoint Blockers

Ó. Lapuente-Santana, F. Eduati. Frontiers in Oncology, 10:1027. 2020.

Patient-specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies

F. Eduati, P. Jaaks, J. Wappler, T. Cramer, C. A. Merten, M. J. Garnett, J. Saez-Rodriguez. Molecular Systems Biology, 16(2),e8664. 2020.

A microfluidics platform for combinatorial drug screening on cancer biopsies.

F. Eduati^$, R. Utharala^$, D. Madhavan, U.P. Neumann, T. Longerich, T. Cramer, J. Saez- Rodriguez^#., C. Merten^#. Nature Communications, 9(1):2434, 2018. (^$ co-first authors, ^# co-last authors)

Multi-Omics Profiling of the Tumor Microenvironment: Paving the Way to Precision Immuno-Oncology.

F. Finotello, F. Eduati. Frontiers in Oncology, 8, 1–9. 2018.

Drug resistance mechanisms in colorectal cancer dissected with cell type-specific dynamic logic models.

F. Eduati, V. Doldàn-Martelli, B. Klinger, T. Cokelaer, A. Sieber, F. Kogera, M. Dorel, M. J. Garnett, N. Blüthgen^#, J. Saez-Rodriguez^#. Cancer Research, 77(12):3364-3375, 2017. (^# co-last authors)

Prediction of human population responses to toxic compounds by a collaborative competition.

F. Eduati^$, L. M. Mangravite^$, T. Wang*, H. Tang*, J. C. Bare, R. Huang, T. Norman, M. Kellen, M. P. Menden, J. Yang, X. Zhan, R. Zhong, G. Xiao, M. Xia, N. Abdo, O. Kosyk, The NIEHS-NCATS-UNC DREAM Collaboration, S. Friend, A. Dearry, A. Simeonov, R. R. Tice, I. Rusyn, F. A. Wright, G. Stolovitzky, Y. Xie, and J. Saez-Rodriguez. Nature Biotechnology, 733(9):933-940, 2015. (^$ co-first authors)